MGP Database

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MGP005588

UniProt Annotations

Entry Information
Gene Namepyridoxal (pyridoxine, vitamin B6) phosphatase
Protein EntryPLPP_HUMAN
UniProt IDQ96GD0
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityO-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate.
Catalytic ActivityPyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}; Note=Divalent metal ions. Mg(2+) is the most effective. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268};
Enzyme RegulationInhibited by NaF, Zn(2+), Ca(2+), Mn(2+) and EDTA. {ECO:0000269|PubMed:15580268}.
FunctionProtein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
InteractionP29066:Arrb1 (xeno); NbExp=2; IntAct=EBI-4303060, EBI-4303019;
SimilarityBelongs to the HAD-like hydrolase superfamily. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.
SubunitHomodimer. {ECO:0000269|PubMed:14522954}.
Tissue SpecificityUbiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
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