MGP Database

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MGP005676

Record overview

MGPD IDMGP005676
Gene ID57761
SpeciesHomo sapiens (Human)
Gene Nametribbles pseudokinase 3
Gene Symbol TRIB3
SynonymsNIPK; SINK; TRB3; SKIP3; C20orf97;
Alternate namestribbles homolog 3; TRB-3; neuronal cell death inducible putative kinase; neuronal cell death-inducible putative kinase; p65-interacting inhibitor of NF-kappa-B; p65-interacting inhibitor of NF-kappaB;
Chromosome20
Map Location20p13-p12.2
SummaryThe protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
OrthologsView orthologs and multiple alignments for TRIB3

Proteins

tribbles homolog 3 isoform 1
Refseq ID:NP_066981
Protein GI:31542265
UniProt ID:Q96RU7
mRNA ID:NM_021158
Length:358
RefSeq Status:
MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRATAVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYP
VQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVL
ENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREP
AERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG
 
tribbles homolog 3 isoform 1
Refseq ID:NP_001288125
Protein GI:668357337
UniProt ID:Q96RU7
mRNA ID:NM_001301196
Length:358
RefSeq Status:
Protein sequence is identical to GI:31542265 (mRNA isoform)
 
tribbles homolog 3 isoform 1
Refseq ID:NP_001288122
Protein GI:668259503
UniProt ID:Q96RU7
mRNA ID:NM_001301193
Length:358
RefSeq Status:
Protein sequence is identical to GI:31542265 (mRNA isoform)
 
tribbles homolog 3 isoform 1
Refseq ID:NP_001288119
Protein GI:668259491
UniProt ID:Q96RU7
mRNA ID:NM_001301190
Length:358
RefSeq Status:
Protein sequence is identical to GI:31542265 (mRNA isoform)
 
tribbles homolog 3 isoform 1
Refseq ID:NP_001288117
Protein GI:668259463
UniProt ID:Q96RU7
mRNA ID:NM_001301188
Length:358
RefSeq Status:
Protein sequence is identical to GI:31542265 (mRNA isoform)
 
tribbles homolog 3 isoform 2
Refseq ID:NP_001288130
Protein GI:668259520
UniProt ID:Q96RU7
mRNA ID:NM_001301201
Length:385
RefSeq Status:
MVLMHLAVKNNRMSANNDHFLTPTWQQMRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRATAVATASRLGPYVL
LEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHC
HQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKI
RRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG
 
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