MGP Database

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MGP005676

Ontology/Pathway Information

Entrez Gene ID57761
Gene Nametribbles pseudokinase 3
Gene Symbol TRIB3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 ISS:UniProtKBCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005524 IEA:InterProFATP binding
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0004860 IEA:UniProtKB-KWFprotein kinase inhibitor activity
GO:0003714 ISS:UniProtKBFtranscription corepressor activity
GO:0016772 IEA:InterProFtransferase activity, transferring phosphorus-containing groups
GO:0031625 ISS:BHF-UCLFubiquitin protein ligase binding
GO:0055106 ISS:BHF-UCLFubiquitin-protein transferase regulator activity
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0032869 ISS:BHF-UCLPcellular response to insulin stimulus
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0070059 IDA:UniProtKBPintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0045599 ISS:BHF-UCLPnegative regulation of fat cell differentiation
GO:0045717 ISS:BHF-UCLPnegative regulation of fatty acid biosynthetic process
GO:0006469 IDA:BHF-UCLPnegative regulation of protein kinase activity
GO:0045892 IMP:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0032092 ISS:BHF-UCLPpositive regulation of protein binding
GO:0051443 ISS:BHF-UCLPpositive regulation of ubiquitin-protein transferase activity
GO:0006468 IEA:InterProPprotein phosphorylation
GO:0010827 ISS:BHF-UCLPregulation of glucose transport
GO:0043405 IDA:UniProtKBPregulation of MAP kinase activity
GO:0034976 IDA:UniProtKBPresponse to endoplasmic reticulum stress
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_790Activation of PKB
REACT_75774Adaptive Immune System
REACT_19183CD28 co-stimulation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_19344Costimulation by the CD28 family
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_12447Negative regulation of the PI3K/AKT network
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_498Signaling by Insulin receptor
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
REACT_263991VEGFR2 mediated vascular permeability
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