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MGP005679

UniProt Annotations

Entry Information
Gene Namepolymerase (DNA-directed), delta 4, accessory subunit
Protein EntryDPOD4_HUMAN
UniProt IDQ9HCU8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HCU8-1; Sequence=Displayed; Name=2; IsoId=Q9HCU8-2; Sequence=VSP_046864; Note=No experimental confirmation available.;
FunctionRequired for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta. {ECO:0000269|PubMed:16510448}.
InteractionP12004:PCNA; NbExp=4; IntAct=EBI-864968, EBI-358311; P28340:POLD1; NbExp=10; IntAct=EBI-864968, EBI-716569; P49005:POLD2; NbExp=3; IntAct=EBI-864968, EBI-372354; Q96S55:WRNIP1; NbExp=2; IntAct=EBI-864968, EBI-2513471;
SimilarityBelongs to the DNA polymerase delta subunit 4 family. {ECO:0000305}.
Subcellular LocationNucleus.
SubunitHeterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1. Interacts with POLD4, POLD2, POLD1 and PCNA. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:16510448}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pold4/";
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