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MGP005681

Record overview

MGPD IDMGP005681
Gene ID57818
SpeciesHomo sapiens (Human)
Gene Nameglucose-6-phosphatase, catalytic, 2
Gene Symbol G6PC2
SynonymsIGRP;
Alternate namesglucose-6-phosphatase 2; G-6-Pase 2; G6Pase 2; islet-specific G6CP-related protein; islet-specific glucose-6-phosphatase catalytic subunit-related protein; islet-specific glucose-6-phosphatase-related protein;
Chromosome2
Map Location2q24.3
EC Number3.1.3.9
SummaryThis gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for G6PC2

Proteins

glucose-6-phosphatase 2 isoform 1
Refseq ID:NP_066999
Protein GI:10863975
UniProt ID:Q9NQR9
mRNA ID:NM_021176
Length:355
RefSeq Status:
MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWVAVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQ
FPTTCETGPGSPSGHAMGASCVWYVMVTAALSHTVCGMDKFSITLHRLTWSFLWSVFWLIQISVCISRVFIATHFPHQVILGVIGGMLVAEAFEHTPGIQ
TASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIAKKWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALTS
LTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQSGKKSQ
 
glucose-6-phosphatase 2 isoform 2
Refseq ID:NP_001075155
Protein GI:126273546
UniProt ID:Q9NQR9
mRNA ID:NM_001081686
Length:154
RefSeq Status:
MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWVAVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQ
FPTTCETGPGSPSGHAMGASCVWYVMVTAALSHTVCGMDKFSITLHRHAGGRGL
 
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