MGP Database

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MGP005681

UniProt Annotations

Entry Information
Gene Nameglucose-6-phosphatase, catalytic, 2
Protein EntryG6PC2_HUMAN
UniProt IDQ9NQR9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NQR9-1; Sequence=Displayed; Name=2; IsoId=Q9NQR9-2; Sequence=VSP_033648, VSP_033649; Note=No experimental confirmation available.; Name=3; IsoId=Q9NQR9-3; Sequence=VSP_046180, VSP_046181; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.45 mM for glucose-6-phosphate (at pH 6.5);
Catalytic ActivityD-glucose 6-phosphate + H(2)O = D-glucose + phosphate. {ECO:0000269|PubMed:14722102}.
FunctionMay hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). {ECO:0000250}.
PathwayCarbohydrate biosynthesis; gluconeogenesis.
PolymorphismGenetic variations in G6PC2 define the fasting plasma glucose levels quantitative trait locus 1 (FGQTL1) [MIM:612108]. The normal fasting plasma glucose level in the plasma is defined as less than 100 mg per deciliter (5.55 mmol per liter). Higher fasting plasma glucose levels predict type 2 diabetes in young adults and increases the risk of mortality.
PtmN-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome. {ECO:0000269|PubMed:15044018}.
SimilarityBelongs to the glucose-6-phosphatase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:15044018}; Multi-pass membrane protein {ECO:0000269|PubMed:15044018}.
Tissue SpecificitySpecifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level). {ECO:0000269|PubMed:11297555}.
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