MGP Database

MGP005744

Record overview

MGPD ID	MGP005744
Gene ID	64116
Species	Homo sapiens (Human)
Gene Name	solute carrier family 39 (zinc transporter), member 8
Gene Symbol	SLC39A8
Synonyms	ZIP8; PP3105; BIGM103; LZT-Hs6;
Alternate names	zinc transporter ZIP8; BCG induced integral membrane protein BIGM103; BCG-induced integral membrane protein in monocyte clone 103 protein; LIV-1 subfamily of ZIP zinc transporter 6; ZIP-8; Zrt- and Irt-like protein 8; solute carrier family 39 (metal ion transporter), member 8; solute carrier family 39 member 8;
Chromosome	4
Map Location	4q24
Summary	This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]
Orthologs	View orthologs and multiple alignments for SLC39A8

Proteins

zinc transporter ZIP8 isoform a precursor

Refseq ID:	NP_001128618
Protein GI:	205830403
UniProt ID:	Q9C0K1
mRNA ID:	NM_001135146
Length:	460
RefSeq Status:

MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLSAAQLQHLLEQMGAASRVGVPEPGQLHFNQCLTAEEIFSLHGFSNATQITSSKFSVI
CPAVLQQLNFHPCEDRPKHKTRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTFFVGLAIGTLFSNAIFQLIPEAFGFDPKVDSYVEKAV
AVFGGFYLLFFFERMLKMLLKTYGQNGHTHFGNDNFGPQEKTHQPKALPAINGVTCYANPAVTEANGHIHFDNVSVVSLQDGKKEPSSCTCLKGPKLSEI
GTIAWMITLCDALHNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAG
GMFLYISLADMFPEMNDMLREKVTGRKTDFTFFMIQNAGMLTGFTAILLITLYAGEIELE

zinc transporter ZIP8 isoform a precursor
`sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1949 peptide sequence: MAPGRAVAGLLLLAAAGLGGVA`

Refseq ID:	NP_071437
Protein GI:	24586665
UniProt ID:	Q9C0K1
mRNA ID:	NM_022154
Length:	460
RefSeq Status:

Protein sequence is identical to GI:205830403 (mRNA isoform)

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1949
peptide sequence: 
MAPGRAVAGLLLLAAAGLGGVA

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1949
peptide sequence: 
MAPGRAVAGLLLLAAAGLGGVA

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1949
peptide sequence: 
MAPGRAVAGLLLLAAAGLGGVA

zinc transporter ZIP8 isoform b precursor

Refseq ID:	NP_001128619
Protein GI:	205830405
UniProt ID:	Q9C0K1
mRNA ID:	NM_001135147
Length:	444
RefSeq Status:

MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLSAAQLQHLLEQMGAASRVGVPEPGQLHFNQCLTAEEIFSLHGFSNATQITSSKFSVI
CPAVLQQLNFHPCEDRPKHKTRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTFFVGLAIGTLFSNAIFQLIPEAFGFDPKVDSYVEKAV
AVFGGFYLLFFFERMLKMLLKTYGQNGHTHFGNDNFGPQEKTHQPKALPAINGVTCYANPAVTEANGHIHFDNVSVVSLQDGKKEPSSCTCLKGPKLSEI
GTIAWMITLCDALHNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAG
GMFLYISLADMFPEMNDMLREKIIKWATDDIKSQLHLLWIYTAR

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1949
peptide sequence: 
MAPGRAVAGLLLLAAAGLGGVA

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1949
peptide sequence: 
MAPGRAVAGLLLLAAAGLGGVA

zinc transporter ZIP8 isoform c

Refseq ID:	NP_001128620
Protein GI:	205830407
UniProt ID:	Q9C0K1
mRNA ID:	NM_001135148
Length:	393
RefSeq Status:

`MHQHAQCLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPCEDRPKHKTRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTFFVG LAIGTLFSNAIFQLIPEAFGFDPKVDSYVEKAVAVFGGFYLLFFFERMLKMLLKTYGQNGHTHFGNDNFGPQEKTHQPKALPAINGVTCYANPAVTEANG HIHFDNVSVVSLQDGKKEPSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALL FNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRKTDFTFFMIQNAGMLTGFTAILLITLYAGEIELE`

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1949
peptide sequence: 
MAPGRAVAGLLLLAAAGLGGVA

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1949
peptide sequence: 
MAPGRAVAGLLLLAAAGLGGVA

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1949
peptide sequence: 
MAPGRAVAGLLLLAAAGLGGVA