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MGP005744

UniProt Annotations

Entry Information
Gene Namesolute carrier family 39 (zinc transporter), member 8
Protein EntryS39A8_HUMAN
UniProt IDQ9C0K1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9C0K1-1; Sequence=Displayed; Name=2; IsoId=Q9C0K1-2; Sequence=VSP_029884, VSP_029885; Note=No experimental confirmation available.; Name=3; IsoId=Q9C0K1-3; Sequence=VSP_043675; Note=No experimental confirmation available.;
FunctionActs as a zinc-influx transporter. {ECO:0000269|PubMed:12504855}.
InductionBy live and heat-killed Mycobacterium bovis bacterial cell wall and inflammatory cytokines like TNF. Down-regulated following phorbol ester treatment. {ECO:0000269|PubMed:12504855}.
SimilarityBelongs to the ZIP transporter (TC 2.A.5) family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Associated with the lysosomal/endosomal compartment following transfection. {ECO:0000269|PubMed:12504855}.
Tissue SpecificityExpressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas. {ECO:0000269|PubMed:12504855}.
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