MGP Database

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MGP005751

UniProt Annotations

Entry Information
Gene Nameendoplasmic reticulum aminopeptidase 2
Protein EntryERAP2_HUMAN
UniProt IDQ6P179
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6P179-1; Sequence=Displayed; Name=2; IsoId=Q6P179-2; Sequence=VSP_030674, VSP_030675; Name=3; IsoId=Q6P179-3; Sequence=VSP_030671; Note=No experimental confirmation available.; Name=4; IsoId=Q6P179-4; Sequence=VSP_030672, VSP_030673; Note=No experimental confirmation available.;
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionAminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. {ECO:0000269|PubMed:12799365, ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653}.
InductionBy IFNG/IFN-gamma. {ECO:0000269|PubMed:15691326, ECO:0000269|PubMed:15908954}.
MiscellaneousDefects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance.
PtmN-glycosylated. {ECO:0000269|PubMed:12799365, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:22106953}.
SimilarityBelongs to the peptidase M1 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:12799365}; Single-pass type II membrane protein {ECO:0000269|PubMed:12799365}.
SubunitHeterodimer with ERAP1. {ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:22106953}.
Tissue SpecificityUbiquitously expressed. Highly expressed in spleen and leukocytes. {ECO:0000269|PubMed:12799365}.
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