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MGP005786

UniProt Annotations

Entry Information
Gene Nameprotein disulfide isomerase family A, member 2
Protein EntryPDIA2_HUMAN
UniProt IDQ13087
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13087-1; Sequence=Displayed; Name=2; IsoId=Q13087-2; Sequence=VSP_039292;
Catalytic ActivityCatalyzes the rearrangement of -S-S- bonds in proteins.
FunctionActs as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins. {ECO:0000269|PubMed:19150607, ECO:0000269|PubMed:19429457}.
InteractionP16333:NCK1; NbExp=3; IntAct=EBI-1752525, EBI-389883;
PtmGlycosylated. {ECO:0000269|PubMed:23167757, ECO:0000269|PubMed:9115635}.
PtmThe disulfide-linked homodimer exhibits an enhanced chaperone activity.
Sequence CautionSequence=AAC50401.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAH75029.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAG58339.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the protein disulfide isomerase family. {ECO:0000305}.
SimilarityContains 2 thioredoxin domains. {ECO:0000255|PROSITE- ProRule:PRU00691}.
Subcellular LocationEndoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
SubunitMonomer; predominantly as monomer under reducing conditions. Homodimer; disulfide-linked. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. {ECO:0000269|PubMed:19150607}.
Tissue SpecificityHighly expressed in pancreas (at protein level). {ECO:0000269|PubMed:19429457, ECO:0000269|PubMed:8561901, ECO:0000269|PubMed:9115635}.
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