MGP Database

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MGP005787

UniProt Annotations

Entry Information
Gene NameSET and MYND domain containing 3
Protein EntrySMYD3_HUMAN
UniProt IDQ9H7B4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H7B4-1; Sequence=Displayed; Name=2; IsoId=Q9H7B4-2; Sequence=VSP_012416, VSP_012417; Note=No experimental confirmation available.; Name=3; IsoId=Q9H7B4-3; Sequence=VSP_035601;
Catalytic ActivityS-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. {ECO:0000255|PROSITE-ProRule:PRU00907, ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:22419068}.
Enzyme RegulationHistone methyltransferase activity strongly stimulated by HSPCA.
FunctionHistone methyltransferase. Specifically methylates 'Lys- 4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. {ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:22419068}.
Sequence CautionSequence=CAI14744.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16628.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. {ECO:0000255|PROSITE-ProRule:PRU00907}.
SimilarityContains 1 MYND-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00134}.
SimilarityContains 1 SET domain. {ECO:0000255|PROSITE- ProRule:PRU00190}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:15235609}. Nucleus {ECO:0000269|PubMed:15235609}. Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.
SubunitInteracts with HSPCA. Interacts with HELZ. Interacts with POLR2A; the interaction may be indirect and may be mediated by HELZ. {ECO:0000269|PubMed:15235609, ECO:0000269|Ref.10}.
Tissue SpecificityExpressed in skeletal muscles and testis. Overexpressed in a majority of colorectal and hepatocellular carcinomas. {ECO:0000269|PubMed:15235609}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SMYD3ID46100ch1q44.html";
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