MGP Database

MGP005800

Record overview

MGPD ID	MGP005800
Gene ID	64849
Species	Homo sapiens (Human)
Gene Name	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Gene Symbol	SLC13A3
Synonyms	NADC3; SDCT2;
Alternate names	solute carrier family 13 member 3; Na(+)/dicarboxylate cotransporter 3; hNaDC3; naDC-3; sodium-dependent high affinity dicarboxylate transporter 3; sodium-dependent high-affinity dicarboxylate transporter 2;
Chromosome	20
Map Location	20q13.12
Summary	Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for SLC13A3

Proteins

solute carrier family 13 member 3 isoform a precursor

Refseq ID:	NP_073740
Protein GI:	31377715
UniProt ID:	Q8WWT9
mRNA ID:	NM_022829
Length:	602
RefSeq Status:

MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMA
SAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLAS
TEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFL
YGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLK
WWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAI
RLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFR
TL

solute carrier family 13 member 3 isoform b
`sig_peptide: 1..33 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3522 peptide sequence: MAALAAAAKKVWSARRLLVLLFTPLALLPVVFA`

Refseq ID:	NP_001011554
Protein GI:	58761541
UniProt ID:	Q8WWT9
mRNA ID:	NM_001011554
Length:	555
RefSeq Status:

MAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTAS
TAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGT
ATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFI
LFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESG
LSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRT
GLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFRTL

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3522
peptide sequence: 
MAALAAAAKKVWSARRLLVLLFTPLALLPVVFA

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3522
peptide sequence: 
MAALAAAAKKVWSARRLLVLLFTPLALLPVVFA

solute carrier family 13 member 3 isoform c precursor

Refseq ID:	NP_001180268
Protein GI:	301069346
UniProt ID:	Q8WWT9
mRNA ID:	NM_001193339
Length:	552
RefSeq Status:

MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMA
SAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENTAKTTLGRQRFHWICRLTPGR
RMNIVGTSGRASSSPSPTQPVLGAQPHSRAQPLTSSCLASSRGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFC
MFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSV
WIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLL
MNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFRTL

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3522
peptide sequence: 
MAALAAAAKKVWSARRLLVLLFTPLALLPVVFA

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3522
peptide sequence: 
MAALAAAAKKVWSARRLLVLLFTPLALLPVVFA

solute carrier family 13 member 3 isoform d

Refseq ID:	NP_001180269
Protein GI:	301069349
UniProt ID:	Q8WWT9
mRNA ID:	NM_001193340
Length:	520
RefSeq Status:

MAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTAS
TAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGT
ATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFLSDAVTG
VAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFA
SNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADM
YSVNVTALPPTLANDTFRTL

solute carrier family 13 member 3 isoform e
`sig_peptide: 1..33 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3522 peptide sequence: MAALAAAAKKVWSARRLLVLLFTPLALLPVVFA`

Refseq ID:	NP_001180271
Protein GI:	301069353
UniProt ID:	B4DF27
mRNA ID:	NM_001193342
Length:	504
RefSeq Status:

MASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFL
ASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWIS
FLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPS
LKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAEL
AIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDT
FRTL

`sig_peptide: 1..33 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3522 peptide sequence: MAALAAAAKKVWSARRLLVLLFTPLALLPVVFA`