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MGP005800

UniProt Annotations

Entry Information
Gene Namesolute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Protein EntryS13A3_HUMAN
UniProt IDQ8WWT9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8WWT9-1; Sequence=Displayed; Name=2; IsoId=Q8WWT9-2; Sequence=VSP_006123, VSP_006124; Note=Gene prediction based on EST data.; Name=3; IsoId=Q8WWT9-3; Sequence=VSP_015291, VSP_015293; Note=No experimental confirmation available.; Name=4; IsoId=Q8WWT9-4; Sequence=VSP_015292, VSP_015294, VSP_015295; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=5; IsoId=Q8WWT9-5; Sequence=VSP_015292; Note=No experimental confirmation available.; Name=6; IsoId=Q8WWT9-6; Sequence=VSP_015291; Note=No experimental confirmation available. Gene prediction based on EST data.;
FunctionHigh-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate.
Sequence CautionSequence=AAF73251.1; Type=Frameshift; Positions=188, 199; Evidence={ECO:0000305}; Sequence=CAC09447.2; Type=Miscellaneous discrepancy; Note=erroneous CDS prediction.; Evidence={ECO:0000305};
SimilarityBelongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:17426067}; Multi-pass membrane protein {ECO:0000269|PubMed:17426067}.
Tissue SpecificityExpression is highest in kidney. Detected in placenta, brain, liver and pancreas.
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