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MGP005803

UniProt Annotations

Entry Information
Gene Namealanine--glyoxylate aminotransferase 2
Protein EntryAGT2_HUMAN
UniProt IDQ9BYV1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BYV1-1; Sequence=Displayed; Name=2; IsoId=Q9BYV1-2; Sequence=VSP_055802; Note=No experimental confirmation available.;
Catalytic ActivityL-alanine + glyoxylate = pyruvate + glycine.
Catalytic Activity(R)-3-amino-2-methylpropanoate + pyruvate = 2- methyl-3-oxopropanoate + L-alanine.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
FunctionCan metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. {ECO:0000269|PubMed:20018850, ECO:0000269|PubMed:23023372}.
SimilarityBelongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:20018850}.
SubunitHomotetramer. {ECO:0000250}.
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