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MGP005859

UniProt Annotations

Entry Information
Gene Namemembrane bound O-acyltransferase domain containing 7
Protein EntryMBOA7_HUMAN
UniProt IDQ96N66
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96N66-1; Sequence=Displayed; Name=2; IsoId=Q96N66-2; Sequence=VSP_030967; Name=3; IsoId=Q96N66-3; Sequence=VSP_030968;
Catalytic ActivityAcyl-[acyl-carrier-protein] + 1-acyl-sn- glycerol 3-phosphate = [acyl-carrier-protein] + 1,2-diacyl-sn- glycerol 3-phosphate. {ECO:0000269|PubMed:18094042}.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphatidylinositol = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylinositol. {ECO:0000269|PubMed:18094042}.
Enzyme RegulationActivity is inhibited by thimerosal.
FunctionAcyltransferase which mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3- phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269|PubMed:18094042, ECO:0000269|PubMed:18772128}.
InteractionQ86WV6:TMEM173; NbExp=2; IntAct=EBI-6116499, EBI-2800345; Q8VCW4:Unc93b1 (xeno); NbExp=2; IntAct=EBI-6116499, EBI-6116986;
PathwayLipid metabolism; phospholipid metabolism. {ECO:0000269|PubMed:18094042}.
Sequence CautionSequence=AAB37433.1; Type=Frameshift; Positions=63, 93, 144, 186; Evidence={ECO:0000305};
SimilarityBelongs to the membrane-bound acyltransferase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityOverexpressed in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium. {ECO:0000269|PubMed:18772128}.
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