MGP Database

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MGP005891

UniProt Annotations

Entry Information
Gene Namepantothenate kinase 3
Protein EntryPANK3_HUMAN
UniProt IDQ9H999
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + (R)-pantothenate = ADP + (R)-4'- phosphopantothenate.
Enzyme RegulationRegulated by feedback inhibition by CoA and its thioesters. {ECO:0000250}.
FunctionPlays a role in the physiological regulation of the intracellular CoA concentration. {ECO:0000250}.
PathwayCofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
SimilarityBelongs to the type II pantothenate kinase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|PubMed:17631502}.
Tissue SpecificityHighly expressed in the liver. {ECO:0000269|PubMed:11479594}.
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