MGP Database

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MGP005896

UniProt Annotations

Entry Information
Gene NameNLR family member X1
Protein EntryNLRX1_HUMAN
UniProt IDQ86UT6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86UT6-1; Sequence=Displayed; Name=2; IsoId=Q86UT6-2; Sequence=VSP_027158, VSP_027159; Note=No experimental confirmation available.;
DomainThe LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers.
FunctionParticipates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}.
InteractionQ6PDS3:Sarm1 (xeno); NbExp=2; IntAct=EBI-3893071, EBI-6117196;
Sequence CautionSequence=BAB15075.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG51714.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG51714.1; Type=Erroneous termination; Positions=951; Note=Translated as Trp.; Evidence={ECO:0000305};
SimilarityBelongs to the NLRP family. {ECO:0000305}.
SimilarityContains 1 LRRCT domain. {ECO:0000305}.
SimilarityContains 1 LRRNT domain. {ECO:0000305}.
SimilarityContains 1 NACHT domain. {ECO:0000255|PROSITE- ProRule:PRU00136}.
SimilarityContains 8 LRR (leucine-rich) repeats. {ECO:0000305}.
Subcellular LocationMitochondrion outer membrane {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}.
SubunitHomohexamer. Interacts with MAVS. {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:22386589}.
Tissue SpecificityUbiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level). {ECO:0000269|PubMed:15952891, ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313}.
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