MGP Database

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MGP005902

Record overview

MGPD IDMGP005902
Gene ID79717
SpeciesHomo sapiens (Human)
Gene Namephosphopantothenoylcysteine synthetase
Gene Symbol PPCS
Alternate namesphosphopantothenate--cysteine ligase; PPC synthetase;
Chromosome1
Map Location1p34.2
EC Number6.3.2.5
SummaryBiosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for PPCS

Proteins

phosphopantothenate--cysteine ligase isoform a
Refseq ID:NP_078940
Protein GI:116875844
UniProt ID:Q9HAB8
mRNA ID:NM_024664
Length:311
RefSeq Status:
MAEMDPVAEFPQPPGAARWAEVMARFAARLGAQGRRVVLVTSGGTKVPLEARPVRFLDNFSSGRRGATSAEAFLAAGYGVLFLYRARSAFPYAHRFPPQT
WLSALRPSGPALSGLLSLEAEENALPGFAEALRSYQEAAAAGTFLAVEFTTLADYLHLLQAAAQALNPLGPSAMFYLAAAVSDFYVPVSEMPEHKIQSSG
GPLQITMKMVPKLLSPLVKDWAPKAFIISFKLETDPAIVINRARKALEIYQHQVVVANILESRQSFVFIVTKDSETKLLLSEEEIEKGVEIEEKIVDNLQ
SRHTAFIGDRN
 
phosphopantothenate--cysteine ligase isoform b
Refseq ID:NP_001070915
Protein GI:116875846
UniProt ID:Q9HAB8
mRNA ID:NM_001077447
Length:138
RefSeq Status:
MFYLAAAVSDFYVPVSEMPEHKIQSSGGPLQITMKMVPKLLSPLVKDWAPKAFIISFKLETDPAIVINRARKALEIYQHQVVVANILESRQSFVFIVTKD
SETKLLLSEEEIEKGVEIEEKIVDNLQSRHTAFIGDRN
 
phosphopantothenate--cysteine ligase isoform b
Refseq ID:NP_001274439
Protein GI:566559813
UniProt ID:Q9HAB8
mRNA ID:NM_001287510
Length:138
RefSeq Status:
Protein sequence is identical to GI:116875846 (mRNA isoform)
 
phosphopantothenate--cysteine ligase isoform b
Refseq ID:NP_001274438
Protein GI:566559920
UniProt ID:Q9HAB8
mRNA ID:NM_001287509
Length:138
RefSeq Status:
Protein sequence is identical to GI:116875846 (mRNA isoform)
 
phosphopantothenate--cysteine ligase isoform b
Refseq ID:NP_001274435
Protein GI:566559886
UniProt ID:Q9HAB8
mRNA ID:NM_001287506
Length:138
RefSeq Status:
Protein sequence is identical to GI:116875846 (mRNA isoform)
 
phosphopantothenate--cysteine ligase isoform b
Refseq ID:NP_001274437
Protein GI:566559832
UniProt ID:Q9HAB8
mRNA ID:NM_001287508
Length:138
RefSeq Status:
Protein sequence is identical to GI:116875846 (mRNA isoform)
 
phosphopantothenate--cysteine ligase isoform c
Refseq ID:NP_001274436
Protein GI:566559963
UniProt ID:
mRNA ID:NM_001287507
Length:105
RefSeq Status:
MKMVPKLLSPLVKDWAPKAFIISFKLETDPAIVINRARKALEIYQHQVVVANILESRQSFVFIVTKDSETKLLLSEEEIEKGVEIEEKIVDNLQSRHTAF
IGDRN
 
phosphopantothenate--cysteine ligase isoform d
Refseq ID:NP_001274440
Protein GI:566559889
UniProt ID:Q9HAB8
mRNA ID:NM_001287511
Length:244
RefSeq Status:
MAEMDPVAEFPQPPGAARWAEVMARFAARLGAQGRRVVLVTSGGTKVPLEARPVRFLDNFSSGRRGATSAEAFLAAGYGVLFLYRARSAFPYAHRFPPQT
WLSALRPSGPALSGLLSLEAEENALPGFAEALRSYQEAAAAGTFLAVEFTTLADYLHLLQAAAQALNPLGPSAMFYLAAAVSDFYVPVSEMPEHKIQSSG
GPLQGKVQLEDILHHLEKEEINPLATTEEQLCLVLIPASTVKTG
 
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