MGP Database

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MGP005902

UniProt Annotations

Entry Information
Gene Namephosphopantothenoylcysteine synthetase
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HAB8-1; Sequence=Displayed; Name=2; IsoId=Q9HAB8-2; Sequence=VSP_045796; Note=No experimental confirmation available.;
Catalytic ActivityCTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine.
FunctionCatalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:12906824}.
MiscellaneousThe mammalian enzyme has a preference for ATP over CTP, in contrast to the E.coli ortholog.
PathwayCofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.
Sequence CautionSequence=BAB13931.1; Type=Frameshift; Positions=282; Evidence={ECO:0000305};
SimilarityBelongs to the PPC synthetase family. {ECO:0000305}.
SubunitHomodimer.
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