MGP Database

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MGP005947

UniProt Annotations

Entry Information
Gene Namewntless Wnt ligand secretion mediator
Protein EntryWLS_HUMAN
UniProt IDQ5T9L3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5T9L3-1; Sequence=Displayed; Name=2; IsoId=Q5T9L3-2; Sequence=VSP_022346, VSP_022347; Name=3; IsoId=Q5T9L3-3; Sequence=VSP_046143; Note=No experimental confirmation available.;
FunctionRegulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). {ECO:0000250}.
InteractionP35372:OPRM1; NbExp=10; IntAct=EBI-2868748, EBI-2624570;
SimilarityBelongs to the wntless family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000269|PubMed:16678095}; Multi-pass membrane protein {ECO:0000269|PubMed:16678095}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16678095}; Multi-pass membrane protein {ECO:0000269|PubMed:16678095}.
SubunitInteracts with WNT3A. Interacts with WNT1, WNT3 and WNT5A (By similarity). {ECO:0000250}.
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