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MGP005965

UniProt Annotations

Entry Information
Gene Namesuppressor of IKBKE 1
Protein EntrySIKE1_HUMAN
UniProt IDQ9BRV8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BRV8-1; Sequence=Displayed; Name=2; IsoId=Q9BRV8-2; Sequence=VSP_027543; Note=No experimental confirmation available.;
FunctionPhysiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways. {ECO:0000269|PubMed:16281057}.
InteractionQ9Y228:TRAF3IP3; NbExp=2; IntAct=EBI-1773646, EBI-765817;
Sequence CautionSequence=CAI18824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the SIKE family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:16281057}.
SubunitInteracts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation. {ECO:0000269|PubMed:16281057}.
Tissue SpecificityWidely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level). {ECO:0000269|PubMed:16281057}.
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