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MGP005966

Record overview

MGPD IDMGP005966
Gene ID80146
SpeciesHomo sapiens (Human)
Gene NameUDP-glucuronate decarboxylase 1
Gene Symbol UXS1
SynonymsUGD; SDR6E1;
Alternate namesUDP-glucuronic acid decarboxylase 1; UXS-1; short chain dehydrogenase/reductase family 6E, member 12;
Chromosome2
Map Location2q12.2
EC Number4.1.1.35
SummaryThis gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
OrthologsView orthologs and multiple alignments for UXS1

Proteins

UDP-glucuronic acid decarboxylase 1 isoform 1
Refseq ID:NP_001240804
Protein GI:359751462
UniProt ID:Q8NBZ7
mRNA ID:NM_001253875
Length:425
RefSeq Status:
MVSKALLRLVSAVNRRRMKLLLGIALLAYVASVWGNFVNMSFLLNRSIQENGELKIESKIEEMVEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITG
GAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGA
RLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQ
TRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKEL
EYQANNQYIPKPKPARIKKGRTRHS
 
UDP-glucuronic acid decarboxylase 1 isoform 2
Refseq ID:NP_079352
Protein GI:42516563
UniProt ID:Q8NBZ7
mRNA ID:NM_025076
Length:420
RefSeq Status:
MVSKALLRLVSAVNRRRMKLLLGIALLAYVASVWGNFVNMRSIQENGELKIESKIEEMVEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFV
GSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLA
STSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQ
YVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQAN
NQYIPKPKPARIKKGRTRHS
 
UDP-glucuronic acid decarboxylase 1 isoform 3
Refseq ID:NP_001240805
Protein GI:359751465
UniProt ID:Q8NBZ7
mRNA ID:NM_001253876
Length:252
RefSeq Status:
MYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHM
NDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKA
KLMLGWEPVVPLEEGLNKAIHYFRKELEYQANNQYIPKPKPARIKKGRTRHS
 
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