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MGP005966

UniProt Annotations

Entry Information
Gene NameUDP-glucuronate decarboxylase 1
Protein EntryUXS1_HUMAN
UniProt IDQ8NBZ7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NBZ7-1; Sequence=Displayed; Name=2; IsoId=Q8NBZ7-2; Sequence=VSP_016757; Name=3; IsoId=Q8NBZ7-3; Sequence=VSP_016756;
Catalytic ActivityUDP-D-glucuronate = UDP-D-xylose + CO(2).
CofactorName=NAD(+); Xref=ChEBI:CHEBI:57540;
FunctionCatalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
PathwayNucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.
SimilarityBelongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. {ECO:0000305}.
Subcellular LocationGolgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
SubunitInteracts with AKT1. {ECO:0000250}.
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