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MGP006040

Record overview

MGPD IDMGP006040
Gene ID81490
SpeciesHomo sapiens (Human)
Gene Namephosphatidylserine synthase 2
Gene Symbol PTDSS2
SynonymsPSS2;
Alternate namesphosphatidylserine synthase 2; PSS-2; ptdSer synthase 2; serine-exchange enzyme II;
Chromosome11
Map Location11p15.5
EC Number2.7.8.29
SummaryPhosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. In addition to its role as a structural component, PS is involved in cell signaling, blood coagulation, and apoptosis. PS is synthesized by a calcium-dependent base-exchange reaction catalyzed by PS synthases (EC 2.7.8.8), like PTDSS2, that exchange L-serine for the polar head group of phosphatidylcholine (PC) or phosphatidylethanolamine (PE) (Sturbois-Balcerzak et al., 2001 [PubMed 11084049]).[supplied by OMIM, May 2009]
OrthologsView orthologs and multiple alignments for PTDSS2

Proteins

phosphatidylserine synthase 2
Refseq ID:NP_110410
Protein GI:13540555
UniProt ID:Q9BVG9
mRNA ID:NM_030783
Length:487
RefSeq Status:
MRRGERRDAGGPRPESPVPAGRASLEEPPDGPSAGQATGPGEGRRSTESEVYDDGTNTFFWRAHTLTVLFILTCTLGYVTLLEETPQDTAYNTKRGIVAS
ILVFLCFGVTQAKDGPFSRPHPAYWRFWLCVSVVYELFLIFILFQTVQDGRQFLKYVDPKLGVPLPERDYGGNCLIYDPDNETDPFHNIWDKLDGFVPAH
FLGWYLKTLMIRDWWMCMIISVMFEFLEYSLEHQLPNFSECWWDHWIMDVLVCNGLGIYCGMKTLEWLSLKTYKWQGLWNIPTYKGKMKRIAFQFTPYSW
VRFEWKPASSLRRWLAVCGIILVFLLAELNTFYLKFVLWMPPEHYLVLLRLVFFVNVGGVAMREIYDFMDDPKPHKKLGPQAWLVAAITATELLIVVKYD
PHTLTLSLPFYISQCWTLGSVLALTWTVWRFFLRDITLRYKETRWQKWQNKDDQGSTVGNGDQHPLGLDEDLLGPGVAEGEGAPTPN
 
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