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MGP006040

UniProt Annotations

Entry Information
Gene Namephosphatidylserine synthase 2
Protein EntryPTSS2_HUMAN
UniProt IDQ9BVG9
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=120 uM for serine (in the presence of 1 mM PE) {ECO:0000269|PubMed:19014349}; Vmax=0.57 mmol/h/mg enzyme {ECO:0000269|PubMed:19014349}; pH dependence: Optimum pH is around 7.5. {ECO:0000269|PubMed:19014349};
Catalytic ActivityL-1-phosphatidylethanolamine + L-serine = L-1- phosphatidylserine + ethanolamine.
Enzyme RegulationInhibited in both the MAM and the ER per se by ethanolamine. Requires calcium ions. {ECO:0000269|PubMed:19014349}.
FunctionCatalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine.
PathwayPhospholipid metabolism; phosphatidylserine biosynthesis.
SimilarityBelongs to the phosphatidyl serine synthase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Highly enriched in the mitochondria-associated membrane (MAM). {ECO:0000250}.
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