MGP Database

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MGP006078

UniProt Annotations

Entry Information
Gene Namenudix (nucleoside diphosphate linked moiety X)-type motif 12
Protein EntryNUD12_HUMAN
UniProt IDQ9BQG2
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=11 uM for NADH {ECO:0000269|PubMed:12790796}; KM=16 uM for NADPH {ECO:0000269|PubMed:12790796}; KM=190 uM for NAD {ECO:0000269|PubMed:12790796}; pH dependence: Optimum pH is 8-9. {ECO:0000269|PubMed:12790796};
Catalytic ActivityNAD(+) + H(2)O = AMP + NMN. {ECO:0000269|PubMed:12790796}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
FunctionHydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. {ECO:0000269|PubMed:12790796}.
SimilarityBelongs to the Nudix hydrolase family. NudC subfamily. {ECO:0000305}.
SimilarityContains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule:PRU00794}.
SimilarityContains 3 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationPeroxisome {ECO:0000269|PubMed:12790796}.
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