MGP Database

MGP006143

Record overview

MGPD ID	MGP006143
Gene ID	84532
Species	Homo sapiens (Human)
Gene Name	acyl-CoA synthetase short-chain family member 1
Gene Symbol	ACSS1
Synonyms	ACAS2L; ACECS1; AceCS2L;
Alternate names	acetyl-coenzyme A synthetase 2-like, mitochondrial; acetate--CoA ligase 2;
Chromosome	20
Map Location	20p11.21
EC Number	6.2.1.1
Summary	This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Orthologs	View orthologs and multiple alignments for ACSS1

Proteins

acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 1 precursor

Refseq ID:	NP_115890
Protein GI:	28416953
UniProt ID:	Q9NUB1
mRNA ID:	NM_032501
Length:	689
RefSeq Status:

MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKI
GWFLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFS
AESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM
PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDA
WVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCIS
QAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD
SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILSVYQKCKDKQAAAK

transit_peptide: 1..37
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000269|PubMed:16788062}; propagated from UniProtKB/Swiss-Prot (Q9NUB1.2)
calculated_mol_wt: 3743
peptide sequence: 
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRA

transit_peptide: 1..37
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000269|PubMed:16788062}; propagated from UniProtKB/Swiss-Prot (Q9NUB1.2)
calculated_mol_wt: 3743
peptide sequence: 
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRA

transit_peptide: 1..37
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000269|PubMed:16788062}; propagated from UniProtKB/Swiss-Prot (Q9NUB1.2)
calculated_mol_wt: 3743
peptide sequence: 
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRA

mat_peptide: 38..689
product: Acetyl-coenzyme A synthetase 2-like, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9NUB1.2)
calculated_mol_wt: 71132
peptide sequence: 
ASGPSGSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGT
EVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDE
AVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADI
GWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRC
TLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYR
TEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPK
TRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILSVYQKCKDKQAAAK

acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 2 precursor

Refseq ID:	NP_001239604
Protein GI:	358248205
UniProt ID:	Q9NUB1
mRNA ID:	NM_001252675
Length:	687
RefSeq Status:

MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKI
GWFLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFS
AESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM
PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDA
WVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQA
WPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSA
GDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILSVYQKCKDKQAAAK

transit_peptide: 1..37
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000269|PubMed:16788062}; propagated from UniProtKB/Swiss-Prot (Q9NUB1.2)
calculated_mol_wt: 3743
peptide sequence: 
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRA

transit_peptide: 1..37
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000269|PubMed:16788062}; propagated from UniProtKB/Swiss-Prot (Q9NUB1.2)
calculated_mol_wt: 3743
peptide sequence: 
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRA

acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 3

Refseq ID:	NP_001239605
Protein GI:	358248211
UniProt ID:	Q9NUB1
mRNA ID:	NM_001252676
Length:	568
RefSeq Status:

MRRRKERQPWDRFHFLHFAPHGRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQ
GLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKL
VFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPIN
CEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAY
FKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIA
KYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILSVYQKCKDKQAAAK

transit_peptide: 1..37
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000269|PubMed:16788062}; propagated from UniProtKB/Swiss-Prot (Q9NUB1.2)
calculated_mol_wt: 3743
peptide sequence: 
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRA

transit_peptide: 1..37
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000269|PubMed:16788062}; propagated from UniProtKB/Swiss-Prot (Q9NUB1.2)
calculated_mol_wt: 3743
peptide sequence: 
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRA

acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 4 precursor

Refseq ID:	NP_001239606
Protein GI:	358248217
UniProt ID:	Q1RMZ4
mRNA ID:	NM_001252677
Length:	575
RefSeq Status:

MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKI
GWFLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFS
AESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM
PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDA
WVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCIS
QAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINILQIVGFFREAIRNSGDLLEH

transit_peptide: 1..37
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000269|PubMed:16788062}; propagated from UniProtKB/Swiss-Prot (Q9NUB1.2)
calculated_mol_wt: 3743
peptide sequence: 
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRA