MGP Database

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MGP006143

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase short-chain family member 1
Protein EntryACS2L_HUMAN
UniProt IDQ9NUB1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9NUB1-1; Sequence=Displayed; Name=2; IsoId=Q9NUB1-2; Sequence=VSP_007249; Note=No experimental confirmation available.; Name=3; IsoId=Q9NUB1-3; Sequence=VSP_044693, VSP_044694; Note=No experimental confirmation available.; Name=4; IsoId=Q9NUB1-4; Sequence=VSP_045546, VSP_045547; Note=No experimental confirmation available.;
Catalytic ActivityATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Enzyme RegulationInhibited by acetylation at Lys-642 and activated by deacetylation. {ECO:0000269|PubMed:16788062}.
FunctionImportant for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2). {ECO:0000250, ECO:0000269|PubMed:16788062}.
PtmReversibly acetylated on Lys-642. The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation. {ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:19608861}.
Sequence CautionSequence=BAB55390.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03853.1; Type=Frameshift; Positions=250; Evidence={ECO:0000305}; Sequence=BAC03853.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:16788062}.
SubunitInteracts with SIRT3. {ECO:0000269|PubMed:19535340}.
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