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MGP006159

UniProt Annotations

Entry Information
Gene Namelysine (K)-specific demethylase 2B
Protein EntryKDM2B_HUMAN
UniProt IDQ8NHM5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8NHM5-1; Sequence=Displayed; Name=2; IsoId=Q8NHM5-2; Sequence=VSP_011340, VSP_011341; Name=3; IsoId=Q8NHM5-3; Sequence=VSP_017475, VSP_017476; Note=No experimental confirmation available.; Name=4; IsoId=Q8NHM5-4; Sequence=VSP_043146, VSP_043147, VSP_043148; Note=No experimental confirmation available.; Name=5; IsoId=Q8NHM5-5; Sequence=VSP_057394, VSP_057395, VSP_057396; Note=No experimental confirmation available.;
Catalytic ActivityProtein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde + CO(2). {ECO:0000269|PubMed:16362057}.
Catalytic ActivityProtein N(6),N(6)-dimethyl-L-lysine + 2- oxoglutarate + O(2) = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2). {ECO:0000269|PubMed:16362057}.
CofactorName=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250};
DomainThe JmjC domain mediates demethylation activity (By similarity). It is also required for repression of ribosomal RNA genes. {ECO:0000250}.
FunctionHistone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099}.
InteractionQ6W2J9:BCOR; NbExp=2; IntAct=EBI-3955564, EBI-950027;
Sequence CautionSequence=AAH08735.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55112.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55301.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11159.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the JHDM1 histone demethylase family. {ECO:0000305}.
SimilarityContains 1 CXXC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00509}.
SimilarityContains 1 F-box domain. {ECO:0000305}.
SimilarityContains 1 JmjC domain. {ECO:0000255|PROSITE- ProRule:PRU00538}.
SimilarityContains 1 PHD-type zinc finger. {ECO:0000255|PROSITE- ProRule:PRU00146}.
SimilarityContains 7 LRR (leucine-rich) repeats. {ECO:0000305}.
Subcellular LocationNucleus, nucleolus {ECO:0000269|PubMed:17994099}.
SubunitDirectly interacts with SKP1 and CUL1. {ECO:0000250}.
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