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MGP Database

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MGP006164

UniProt Annotations

Entry Information

Gene Name	glutamic pyruvate transaminase (alanine aminotransferase) 2
Protein Entry	ALAT2_HUMAN
UniProt ID	Q8TD30
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TD30-1; Sequence=Displayed; Name=2; IsoId=Q8TD30-2; Sequence=VSP_020008;
Catalytic Activity	L-alanine + 2-oxoglutarate = pyruvate + L- glutamate. {ECO:0000269\|PubMed:11863375}.
Cofactor	Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269\|Ref.6};
Function	Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. {ECO:0000269\|PubMed:11863375}.
Pathway	Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.
Similarity	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. {ECO:0000305}.
Subunit	Homodimer. {ECO:0000250}.
Tissue Specificity	Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast. {ECO:0000269\|PubMed:11863375}.