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MGP006507

Record overview

MGPD IDMGP006507
Gene ID130013
SpeciesHomo sapiens (Human)
Gene Nameaminocarboxymuconate semialdehyde decarboxylase
Gene Symbol ACMSD
Alternate names2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase;
Chromosome2
Map Location2q21.3
EC Number4.1.1.45
SummaryThe neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
OrthologsView orthologs and multiple alignments for ACMSD

Proteins

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Refseq ID:NP_612199
Protein GI:109715856
UniProt ID:Q8TDX5
mRNA ID:NM_138326
Length:336
RefSeq Status:
MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDL
ASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETT
IAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELE
PGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
 
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