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MGP006507

UniProt Annotations

Entry Information
Gene Nameaminocarboxymuconate semialdehyde decarboxylase
Protein EntryACMSD_HUMAN
UniProt IDQ8TDX5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1 {ECO:0000269|PubMed:12140278}; IsoId=Q8TDX5-1; Sequence=Displayed; Name=2 {ECO:0000305}; IsoId=Q8TDX5-2; Sequence=VSP_050622, VSP_050623; Note=No experimental confirmation available. {ECO:0000305};
Catalytic Activity2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO(2). {ECO:0000269|PubMed:12140278}.
FunctionConverts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. {ECO:0000269|PubMed:19843166}.
PathwaySecondary metabolite metabolism; quinolate metabolism.
SimilarityBelongs to the ACMSD family. {ECO:0000305}.
SubunitMonomer. {ECO:0000269|PubMed:19843166}.
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