MGP Database

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MGP006612

UniProt Annotations

Entry Information
Gene Namephosphoinositide-3-kinase, regulatory subunit 6
Protein EntryPI3R6_HUMAN
UniProt IDQ5UE93
SpeciesHuman
Comments
Comment typeDescription
FunctionRegulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269|PubMed:21393242}.
InteractionQ13370:PDE3B; NbExp=3; IntAct=EBI-6172907, EBI-6172856;
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHeterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG. Interacts with beta-gamma G protein dimers. Interacts with PDE3B; the interaction allows recruitment of the PI3K gamma complex to a PDE3B:RAPGEF3 complex. {ECO:0000269|PubMed:21393242}.
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