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MGP006665

Record overview

MGPD IDMGP006665
Gene ID155066
SpeciesHomo sapiens (Human)
Gene NameATPase, H+ transporting V0 subunit e2
Gene Symbol ATP6V0E2
SynonymsC7orf32; ATP6V0E2L;
Alternate namesV-type proton ATPase subunit e 2; H+-ATPase e2 subunit; V-ATPase subunit e 2; lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2; vacuolar proton pump subunit e 2; vacuolar proton-ATPase subunit;
Chromosome7
Map Location7q36.1
SummaryMultisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and sperm maturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transport H+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodes an isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 [PubMed 17350184]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for ATP6V0E2

Proteins

V-type proton ATPase subunit e 2 isoform 1
Refseq ID:NP_660265
Protein GI:154689666
UniProt ID:Q8NHE4
mRNA ID:NM_145230
Length:130
RefSeq Status:
MRVRGPARLIASGARLLLRMLSALPGWGPAHLQRPLLGPASCLGILRPAMTAHSFALPVIIFTTFWGLVGIAGPWFVPKGPNRGVIITMLVATAVCCYLF
WLIAILAQLNPLFGPQLKNETIWYVRFLWE
 
V-type proton ATPase subunit e 2 isoform 2
Refseq ID:NP_001094062
Protein GI:154689796
UniProt ID:Q8NHE4
mRNA ID:NM_001100592
Length:213
RefSeq Status:
MRVRGPARLIASGARLLLRMLSALPGWGPAHLQRPLLGPASCLGILRPAMTAHSFALPVIIFTTFWGLVGIAGPWFVPKGPNRGVIITMLVATAVCCYLL
CPALGMTVAPLSLTTPSSGPSPTQLCLVTSSLLLAPRDPDPQGLPGSWKSSQSSQPARALGSPGHSSGRGDVLLQYPHCSGVCPLSQGDAAGELVWVGSF
PLQTGQMPGLSPS
 
V-type proton ATPase subunit e 2 isoform 3
Refseq ID:NP_001276919
Protein GI:585635062
UniProt ID:Q8NHE4
mRNA ID:NM_001289990
Length:236
RefSeq Status:
MRVRGPARLIASGARLLLRMLSALPGWGPAHLQRPLLGPASCLGILRPAMTAHSFALPVIIFTTFWGLVGIAGPWFVPKGPNRGVIITMLVATAVCCYLF
WLIAILAQLNPLFGPQLKNETIWCPALGMTVAPLSLTTPSSGPSPTQLCLVTSSLLLAPRDPDPQGLPGSWKSSQSSQPARALGSPGHSSGRGDVLLQYP
HCSGVCPLSQGDAAGELVWVGSFPLQTGQMPGLSPS
 
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