MGP Database

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MGP006665

UniProt Annotations

Entry Information
Gene NameATPase, H+ transporting V0 subunit e2
Protein EntryVA0E2_HUMAN
UniProt IDQ8NHE4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NHE4-1; Sequence=Displayed; Name=2; IsoId=Q8NHE4-2; Sequence=VSP_027104; Name=3; IsoId=Q8NHE4-3; Sequence=VSP_027105; Note=May be due to a competing donor splice site.; Name=4; IsoId=Q8NHE4-4; Sequence=VSP_044857; Note=No experimental confirmation available.;
FunctionVacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. {ECO:0000250}.
Sequence CautionSequence=AAP97693.1; Type=Frameshift; Positions=80, 108; Evidence={ECO:0000305}; Sequence=AAQ96859.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC05292.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAE45916.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the V-ATPase e1/e2 subunit family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
SubunitComposed of at least 10 subunits.
Tissue SpecificityIsoform 1 is expressed at high levels in heart, brain and kidney and also detected in inner ear epithelium, vestibule, testis, epididymis and bladder. Isoform 2 is expressed in heart, kidney, placenta and pancreas. Isoform 2 is not detected in frontal cortex, but is prevalent in all other brain areas. {ECO:0000269|PubMed:17350184}.
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