MGP Database

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MGP006739

Ontology/Pathway Information

Entrez Gene ID196743
Gene Namepolyamine oxidase (exo-N4-amino)
Gene Symbol PAOX
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005782 TAS:ReactomeCperoxisomal matrix
GO:0052904 TAS:ReactomeFN1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052903 IEA:UniProtKB-ECFN1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052899 IEA:UniProtKB-ECFN(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0046592 IDA:UniProtKBFpolyamine oxidase activity
GO:0005102 IPI:UniProtKBFreceptor binding
GO:0052902 IEA:UniProtKB-ECFspermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
GO:0052901 IEA:UniProtKB-ECFspermine:oxygen oxidoreductase (spermidine-forming) activity
GO:0034641 TAS:ReactomePcellular nitrogen compound metabolic process
GO:0055114 IDA:GOCPoxidation-reduction process
GO:0006596 TAS:ReactomePpolyamine biosynthetic process
GO:0006598 IDA:UniProtKBPpolyamine catabolic process
GO:0006595 TAS:ReactomePpolyamine metabolic process
GO:1901307 IDA:UniProtKBPpositive regulation of spermidine biosynthetic process
GO:0009446 IDA:UniProtKBPputrescine biosynthetic process
GO:0009447 IDA:UniProtKBPputrescine catabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0046203 IDA:UniProtKBPspermidine catabolic process
GO:0046208 IDA:UniProtKBPspermine catabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1875Amine Oxidase reactions
REACT_13433Biological oxidations
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_14805Interconversion of polyamines
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_13Metabolism of amino acids and derivatives
REACT_14820Metabolism of polyamines
REACT_505PAOs oxidise polyamines to amines
REACT_13705Phase 1 - Functionalization of compounds
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