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MGP006739

UniProt Annotations

Entry Information
Gene Namepolyamine oxidase (exo-N4-amino)
Protein EntryPAOX_HUMAN
UniProt IDQ6QHF9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=11; Name=9; IsoId=Q6QHF9-1; Sequence=Displayed; Name=1; IsoId=Q6QHF9-2; Sequence=VSP_011249; Name=3; Synonyms=7; IsoId=Q6QHF9-6; Sequence=VSP_011250, VSP_011251; Name=4; Synonyms=2; IsoId=Q6QHF9-5; Sequence=VSP_011249, VSP_011255, VSP_011257; Name=5; IsoId=Q6QHF9-4; Sequence=VSP_011249, VSP_011258; Note=Ref.2 (AAS64376) sequence is in conflict in position: 457:Q->E. {ECO:0000305}; Name=6; IsoId=Q6QHF9-8; Sequence=VSP_011248, VSP_011256; Note=Ref.2 (AAS64377) sequence differs from that shown due to a frameshift in position 26. {ECO:0000305}; Name=8; IsoId=Q6QHF9-3; Sequence=VSP_011249, VSP_011254; Name=10; IsoId=Q6QHF9-7; Sequence=VSP_011252; Name=11; IsoId=Q6QHF9-9; Sequence=VSP_011247, VSP_011253; Name=12; IsoId=Q6QHF9-10; Sequence=VSP_011259, VSP_011260; Name=13; IsoId=Q6QHF9-11; Sequence=VSP_011261, VSP_011262;
Catalytic ActivityN(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2).
Catalytic ActivityN(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2).
Catalytic ActivityN(1),N(12)-diacetylspermine + O(2) + H(2)O = N(1)-acetylspermidine + 3-acetamidobutanal + H(2)O(2).
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; Note=Binds 1 FAD per subunit. {ECO:0000250};
FunctionFlavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
InductionBy polyamine analogs.
MiscellaneousOxidizes N(1)-acetylated polyamines on the exo-side of their N(4)-amino groups. Plant PAO oxidizes spermine on the endo-side of the N(4)-nitrogen (By similarity). {ECO:0000250}.
PathwayAmine and polyamine metabolism; spermine metabolism.
SimilarityBelongs to the flavin monoamine oxidase family. {ECO:0000305}.
Subcellular LocationPeroxisome {ECO:0000250}. Cytoplasm {ECO:0000250}.
SubunitMonomer. {ECO:0000250}.
Tissue SpecificityWidely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues. {ECO:0000269|PubMed:12477380}.
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