MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP006753

Ontology/Pathway Information

Entrez Gene ID200895
Gene Namedihydrofolate reductase-like 1
Gene Symbol DHFRL1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005743 IMP:UniProtKBCmitochondrial inner membrane
GO:0005759 IMP:UniProtKBCmitochondrial matrix
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0004146 IMP:UniProtKBFdihydrofolate reductase activity
GO:0003729 IDA:UniProtKBFmRNA binding
GO:0050661 IEA:InterProFNADP binding
GO:0006545 IEA:InterProPglycine biosynthetic process
GO:0009165 IEA:InterProPnucleotide biosynthetic process
GO:0006730 IEA:UniProtKB-KWPone-carbon metabolic process
GO:0046654 IEA:UniProtKB-UniPathwayPtetrahydrofolate biosynthetic process
GO:0046653 IDA:UniProtKBPtetrahydrofolate metabolic process
GO:0046105 IDA:UniProtKBPthymidine biosynthetic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_111217Metabolism
REACT_11167Metabolism of folate and pterines
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors
  logo