MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP006753

UniProt Annotations

Entry Information
Gene Namedihydrofolate reductase-like 1
Protein EntryDYRL1_HUMAN
UniProt IDQ86XF0
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=209 uM for dihydrofolate {ECO:0000269|PubMed:21876184}; KM=20 uM for NADPH {ECO:0000269|PubMed:21876184};
Catalytic Activity5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH. {ECO:0000255|PROSITE-ProRule:PRU00660, ECO:0000269|PubMed:21876184}.
FunctionKey enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. {ECO:0000269|PubMed:21876184, ECO:0000269|PubMed:21876188}.
PathwayCofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
SimilarityBelongs to the dihydrofolate reductase family. {ECO:0000305}.
SimilarityContains 1 DHFR (dihydrofolate reductase) domain. {ECO:0000255|PROSITE-ProRule:PRU00660}.
Subcellular LocationMitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.
Tissue SpecificityExpressed in numerous cell lines. {ECO:0000269|PubMed:21876184}.
  logo