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MGP006829

UniProt Annotations

Entry Information
Gene Namephosphoribosyl pyrophosphate synthetase 1-like 1
Protein EntryPRPS3_HUMAN
UniProt IDP21108
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate.
CautionAccording to PubMed:2168892, this sequence initiates from a non-AUG codon; N-terminal ACG codon did serve as a start codon. {ECO:0000305}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme RegulationActivated by magnesium and inorganic phosphate.
FunctionCatalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
PathwayMetabolic intermediate biosynthesis; 5-phospho-alpha-D- ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1- diphosphate from D-ribose 5-phosphate (route I): step 1/1.
SimilarityBelongs to the ribose-phosphate pyrophosphokinase family. {ECO:0000305}.
SubunitHomodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity). {ECO:0000250}.
Tissue SpecificityTestis.
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