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MGP006856

Record overview

MGPD IDMGP006856
Gene ID245973
SpeciesHomo sapiens (Human)
Gene NameATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
Gene Symbol ATP6V1C2
SynonymsVMA5; ATP6C2;
Alternate namesV-type proton ATPase subunit C 2; V-ATPase C2 subunit; V-ATPase subunit C 2; vacuolar proton pump subunit C 2;
Chromosome2
Map Locationchromosome:2
SummaryThis gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ATP6V1C2

Proteins

V-type proton ATPase subunit C 2 isoform a
Refseq ID:NP_001034451
Protein GI:87159812
UniProt ID:Q8NEY4
mRNA ID:NM_001039362
Length:427
RefSeq Status:
MSEFWLISAPGDKENLQALERMNTVTSKSNLSYNTKFAIPDFKVGTLDSLVGLSDELGKLDTFAESLIRRMAQSVVEVMEDSKGKVQEHLLANGVDLTSF
VTHFEWDMAKYPVKQPLVSVVDTIAKQLAQIEMDLKSRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVLDSEYLVTLLVIVPKPNYSQWQKTY
ESLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYDEKEIEREREEMARLLSDKKQQYQTSCVALKKGSSTFPDHKVKVTPLG
NPDRPAAGQTDRERESEGEGEGPLLRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAVLLQPHKKSSTKRLREVLNSVFRHLDEVAATSILDAS
VEIPGLQLNNQDYFPYVYFHIDLSLLD
 
V-type proton ATPase subunit C 2 isoform b
Refseq ID:NP_653184
Protein GI:47717098
UniProt ID:Q8NEY4
mRNA ID:NM_144583
Length:381
RefSeq Status:
MSEFWLISAPGDKENLQALERMNTVTSKSNLSYNTKFAIPDFKVGTLDSLVGLSDELGKLDTFAESLIRRMAQSVVEVMEDSKGKVQEHLLANGVDLTSF
VTHFEWDMAKYPVKQPLVSVVDTIAKQLAQIEMDLKSRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVLDSEYLVTLLVIVPKPNYSQWQKTY
ESLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYDEKEIEREREEMARLLSDKKQQYGPLLRWLKVNFSEAFIAWIHIKALR
VFVESVLRYGLPVNFQAVLLQPHKKSSTKRLREVLNSVFRHLDEVAATSILDASVEIPGLQLNNQDYFPYVYFHIDLSLLD
 
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