MGP Database

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MGP006856

UniProt Annotations

Entry Information
Gene NameATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
Protein EntryVATC2_HUMAN
UniProt IDQ8NEY4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NEY4-1; Sequence=Displayed; Name=2; IsoId=Q8NEY4-2; Sequence=VSP_024883;
FunctionSubunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Sequence CautionSequence=AAY24069.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the V-ATPase C subunit family. {ECO:0000305}.
SubunitV-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Tissue SpecificityKidney and placenta. {ECO:0000269|PubMed:12384298}.
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