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MGP006865

UniProt Annotations

Entry Information
Gene Namecell adhesion molecule 2
Protein EntryCADM2_HUMAN
UniProt IDQ8N3J6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8N3J6-1; Sequence=Displayed; Name=2; IsoId=Q8N3J6-2; Sequence=VSP_026334, VSP_026335; Name=3; IsoId=Q8N3J6-3; Sequence=VSP_026333; Name=5; Synonyms=7; IsoId=Q8N3J6-4; Sequence=VSP_055355, VSP_055356; Name=6; Synonyms=8; IsoId=Q8N3J6-5; Sequence=VSP_055355;
FunctionAdhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. {ECO:0000269|PubMed:17967169}.
SimilarityBelongs to the nectin family. {ECO:0000305}.
SimilarityContains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
SimilarityContains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:17967169}; Single-pass type I membrane protein {ECO:0000269|PubMed:17967169}. Cell junction, synapse {ECO:0000269|PubMed:17967169}. Cell projection, axon {ECO:0000269|PubMed:17967169}. Note=Found in the axoplasm of myelinated axons.
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