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MGP006870

UniProt Annotations

Entry Information
Gene Namelysophosphatidylcholine acyltransferase 4
Protein EntryLPCT4_HUMAN
UniProt IDQ643R3
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=80 uM for lysophosphatidylethanolamine {ECO:0000269|PubMed:18458083}; KM=20 uM for oleoyl-CoA {ECO:0000269|PubMed:18458083}; Vmax=270 pmol/min/mg enzyme with lysophosphatidylethanolamine and oleoyl-CoA as substrates {ECO:0000269|PubMed:18458083};
Catalytic ActivityAcetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine. {ECO:0000269|PubMed:18458083}.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine. {ECO:0000269|PubMed:18458083}.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:18458083}.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine. {ECO:0000269|PubMed:18458083}.
Catalytic ActivityAcyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine. {ECO:0000269|PubMed:18458083}.
FunctionDisplays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. {ECO:0000269|PubMed:18458083}.
PathwayLipid metabolism; phospholipid metabolism.
Sequence CautionSequence=AAC19156.1; Type=Frameshift; Positions=328; Evidence={ECO:0000305}; Sequence=AAC19156.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAN33178.1; Type=Frameshift; Positions=198; Evidence={ECO:0000305}; Sequence=AAP97722.1; Type=Frameshift; Positions=188, 198; Evidence={ECO:0000305};
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:16243729, ECO:0000269|PubMed:18458083}; Multi- pass membrane protein {ECO:0000269|PubMed:16243729, ECO:0000269|PubMed:18458083}.
Tissue SpecificityWidely expressed with predominant level in brain. {ECO:0000269|PubMed:16243729, ECO:0000269|PubMed:18458083}.
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