MGP Database

MGP006909

Record overview

MGPD ID	MGP006909
Gene ID	259307
Species	Homo sapiens (Human)
Gene Name	interleukin 4 induced 1
Gene Symbol	IL4I1
Synonyms	LAO; FIG1; LAAO;
Alternate names	L-amino-acid oxidase; Fig-1 protein; IL4-induced protein 1; interleukin four induced 1;
Chromosome	19
Map Location	19q13.3-q13.4
EC Number	1.4.3.2
Summary	This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Orthologs	View orthologs and multiple alignments for IL4I1

Proteins

L-amino-acid oxidase isoform 1 precursor

Refseq ID:	NP_690863
Protein GI:	23821023
UniProt ID:	Q96RQ9
mRNA ID:	NM_152899
Length:	567
RefSeq Status:

MAPLALHLLVLVPILLSLVASQDWKAERSQDPFEKCMQDPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFT
YRDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYVVEKVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCR
KAMKKFERHTLLEYLLGEGNLSRPAVQLLGDVMSEDGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQ
IETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASYTW
SDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQPPALWQTEKDDWTVPYGRIYFAGEHTAYPHGWVETAVKSALRA
AIKINSRKGPASDTASPEGHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH

sig_peptide: 1..43
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4631
peptide sequence: 
MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVAS

sig_peptide: 1..43
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4631
peptide sequence: 
MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVAS

sig_peptide: 1..43
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4631
peptide sequence: 
MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVAS

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2184
peptide sequence: 
MAPLALHLLVLVPILLSLVAS

mat_peptide: 22..567
product: L-amino-acid oxidase isoform 1
calculated_mol_wt: 60715
peptide sequence: 
QDWKAERSQDPFEKCMQDPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFTYRDQNTGWIGELGAMRMPSSH
RILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYVVEKVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGEGNL
SRPAVQLLGDVMSEDGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLT
ASGPAVKRITFSPPLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASYTWSDAAAAFAGLSREEALRLALD
DVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQPPALWQTEKDDWTVPYGRIYFAGEHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPEGHA
SDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH

L-amino-acid oxidase isoform 2 precursor

Refseq ID:	NP_758962
Protein GI:	27477089
UniProt ID:	Q96RQ9
mRNA ID:	NM_172374
Length:	589
RefSeq Status:

MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVASQDWKAERSQDPFEKCMQDPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVL
SDAGHKVTILEADNRIGGRIFTYRDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYVVEKVPEKLGYALRPQEKGHS
PEDIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGEGNLSRPAVQLLGDVMSEDGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLS
GLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDR
PSRMIFYPPPREGALLLASYTWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQPPALWQTEKDDWTVPYGRIYF
AGEHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPEGHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH

L-amino-acid oxidase isoform 2 precursor
`sig_peptide: 1..43 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 4631 peptide sequence: MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVAS`

Refseq ID:	NP_001244946
Protein GI:	384381475
UniProt ID:	Q96RQ9
mRNA ID:	NM_001258017
Length:	589
RefSeq Status:

Protein sequence is identical to GI:27477089 (mRNA isoform)

sig_peptide: 1..43
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4631
peptide sequence: 
MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVAS

sig_peptide: 1..43
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4631
peptide sequence: 
MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVAS

sig_peptide: 1..43
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4631
peptide sequence: 
MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVAS

L-amino-acid oxidase isoform 2 precursor

Refseq ID:	NP_001244947
Protein GI:	384381477
UniProt ID:	Q96RQ9
mRNA ID:	NM_001258018
Length:	589
RefSeq Status:

Protein sequence is identical to GI:27477089 (mRNA isoform)

sig_peptide: 1..43
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4631
peptide sequence: 
MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVAS

sig_peptide: 1..43
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4631
peptide sequence: 
MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVAS