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MGP006909

UniProt Annotations

Entry Information
Gene Nameinterleukin 4 induced 1
Protein EntryOXLA_HUMAN
UniProt IDQ96RQ9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage, Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96RQ9-1; Sequence=Displayed; Name=2; Synonyms=IL4I1_2; IsoId=Q96RQ9-2; Sequence=VSP_017173; Note=Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62.;
Catalytic ActivityAn L-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2).
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
FunctionLysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity). {ECO:0000250}.
InductionBy IL4/interleukin-4.
Sequence CautionSequence=BAB84923.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI54291.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI54292.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI54293.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the flavin monoamine oxidase family. FIG1 subfamily. {ECO:0000305}.
Subcellular LocationIsoform 1: Lysosome {ECO:0000250}.
Subcellular LocationIsoform 2: Lysosome {ECO:0000250}.
Tissue SpecificityIsoform 1 is primarily found in immune tissues. {ECO:0000269|PubMed:12031486}.
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