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MGP007013

Record overview

MGPD IDMGP007013
Gene ID340485
SpeciesHomo sapiens (Human)
Gene Namealkaline ceramidase 2
Gene Symbol ACER2
SynonymsASAH3L; ALKCDase2;
Alternate namesalkaline ceramidase 2; alkCDase 2; alkaline CDase 2; ceramide hydrolase; haCER2;
Chromosome9
Map Location9p22.1
EC Number3.5.1.23
SummaryThe sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]
OrthologsView orthologs and multiple alignments for ACER2

Proteins

alkaline ceramidase 2
Refseq ID:NP_001010887
Protein GI:71043498
UniProt ID:Q5QJU3
mRNA ID:NM_001010887
Length:275
RefSeq Status:
MGAPHWWDQLQAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAVLWV
LMCALAMWFPRRYLPKIFRNDRGRFKVVVSVLSAVTTCLAFVKPAINNISLMTLGVPCTALLIAELKRCDNMRVFKLGLFSGLWWTLALFCWISDRAFCE
LLSSFNFPYLHCMWHILICLAAYLGCVCFAYFDAASEIPEQGPVIKFWPNEKWAFIGVPYVSLLCANKKSSVKIT
 
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