MGP Database

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MGP007269

Ontology/Pathway Information

Entrez Gene ID729230
Gene Namechemokine (C-C motif) receptor 2
Gene Symbol CCR2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:MGICcytoplasm
GO:0005829 ISS:BHF-UCLCcytosol
GO:0030425 ISS:BHF-UCLCdendrite
GO:0016021 TAS:ProtIncCintegral component of membrane
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0043025 ISS:BHF-UCLCneuronal cell body
GO:0043204 ISS:BHF-UCLCperikaryon
GO:0048471 ISS:BHF-UCLCperinuclear region of cytoplasm
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0016493 IEA:InterProFC-C chemokine receptor activity
GO:0031727 IDA:MGIFCCR2 chemokine receptor binding
GO:0004950 TAS:ProtIncFchemokine receptor activity
GO:0042803 ISS:BHF-UCLFprotein homodimerization activity
GO:0001974 ISS:BHF-UCLPblood vessel remodeling
GO:0006874 ISS:BHF-UCLPcellular calcium ion homeostasis
GO:0006968 TAS:ProtIncPcellular defense response
GO:0019725 ISS:BHF-UCLPcellular homeostasis
GO:0070098 ISS:BHF-UCLPchemokine-mediated signaling pathway
GO:0006935 TAS:ProtIncPchemotaxis
GO:0019221 IDA:MGIPcytokine-mediated signaling pathway
GO:0002407 TAS:BHF-UCLPdendritic cell chemotaxis
GO:0006955 TAS:ProtIncPimmune response
GO:0006954 TAS:ProtIncPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0007259 TAS:ProtIncPJAK-STAT cascade
GO:0007194 TAS:ProtIncPnegative regulation of adenylate cyclase activity
GO:0016525 ISS:BHF-UCLPnegative regulation of angiogenesis
GO:0043310 ISS:BHF-UCLPnegative regulation of eosinophil degranulation
GO:0002829 ISS:BHF-UCLPnegative regulation of type 2 immune response
GO:0046641 ISS:BHF-UCLPpositive regulation of alpha-beta T cell proliferation
GO:2000464 IDA:BHF-UCLPpositive regulation of astrocyte chemotaxis
GO:2000451 ISS:BHF-UCLPpositive regulation of CD8-positive, alpha-beta T cell extravasation
GO:0007204 TAS:ProtIncPpositive regulation of cytosolic calcium ion concentration
GO:2000473 ISS:BHF-UCLPpositive regulation of hematopoietic stem cell migration
GO:0090265 ISS:BHF-UCLPpositive regulation of immune complex clearance by monocytes and macrophages
GO:0050729 ISS:BHF-UCLPpositive regulation of inflammatory response
GO:0032729 ISS:BHF-UCLPpositive regulation of interferon-gamma production
GO:0032743 ISS:BHF-UCLPpositive regulation of interleukin-2 production
GO:0090026 IDA:UniProtKBPpositive regulation of monocyte chemotaxis
GO:2000439 ISS:BHF-UCLPpositive regulation of monocyte extravasation
GO:0050870 ISS:BHF-UCLPpositive regulation of T cell activation
GO:0010820 ISS:BHF-UCLPpositive regulation of T cell chemotaxis
GO:0002827 ISS:BHF-UCLPpositive regulation of T-helper 1 type immune response
GO:0042535 ISS:BHF-UCLPpositive regulation of tumor necrosis factor biosynthetic process
GO:0010574 ISS:BHF-UCLPregulation of vascular endothelial growth factor production
GO:0009611 TAS:ProtIncPresponse to wounding
GO:0035705 ISS:BHF-UCLPT-helper 17 cell chemotaxis
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115897Beta defensins
REACT_15344Chemokine receptors bind chemokines
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_115846Defensins
REACT_116125Disease
REACT_19231G alpha (i) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14819Peptide ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
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