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MGP007269

UniProt Annotations

Entry Information
Gene Namechemokine (C-C motif) receptor 2
Protein EntryCCR2_HUMAN
UniProt IDP41597
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=A; IsoId=P41597-1; Sequence=Displayed; Name=B; IsoId=P41597-2; Sequence=VSP_001893;
FunctionReceptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:23408426}.
InductionUp-regulated by CREB3. {ECO:0000269|PubMed:18587271}.
PolymorphismVariations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423].
PtmN-glycosylated. {ECO:0000269|PubMed:11046064}.
PtmSulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer. {ECO:0000269|PubMed:11046064, ECO:0000269|PubMed:23408426}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:18587271}; Multi-pass membrane protein {ECO:0000269|PubMed:18587271}.
SubunitBinds to HIV-1 Tat. Interacts with ARRB1. {ECO:0000269|PubMed:9501202, ECO:0000269|PubMed:9789057}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CCR2ID964ch3p21.html";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ccr2/";
Web ResourceName=Wikipedia; Note=CC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CC_chemokine_receptors";
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