Summary of Study ST002432

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001565. The data can be accessed directly via it's Project DOI: 10.21228/M8DD8S This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002432
Study TitleMetabolic impacts of metformin to seasonal influenza vaccination: a pilot study of drug interaction with the immune response
Study SummaryWe report here a double-blinded pilot study of seasonal influenza vaccination, where half of the participants received daily metformin administration. Global metabolomics was measured in the plasma samples at six timepoints. Metformin signatures were successfully identified in the metabolomics data. Statistically significant metabolite features were found both for the vaccination effect and for the drug-vaccine interactions.
Institute
The Jackson Laboratory for Genomic Medicine
LaboratoryShuzhao Li Lab
Last NameSiddiqa
First NameAmnah
Address10 Discovery dr, Farmington, CT 06032
Emailamnah.siddiqa@jax.org
Phone4049187223
Submit Date2023-01-04
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2023-01-20
Release Version1
Amnah Siddiqa Amnah Siddiqa
https://dx.doi.org/10.21228/M8DD8S
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN003959 AN003960 AN003961 AN003962
Analysis type MS MS MS MS
Chromatography type HILIC HILIC Reversed phase Reversed phase
Chromatography system Thermo Scientific Transcend Duo LX-2 UHPLC Thermo Scientific Transcend Duo LX-2 UHPLC Thermo Scientific Transcend Duo LX-2 UHPLC Thermo Scientific Transcend Duo LX-2 UHPLC
Column Thermo Accucore 150 Amide (50 x 2.1mm, 2.6um) Thermo Accucore 150 Amide (50 x 2.1mm, 2.6um) Thermo Hypersil GOLD RP (50 x 2.1mm, 3um) Thermo Hypersil GOLD RP (50 x 2.1mm, 3um)
MS Type ESI ESI ESI ESI
MS instrument type Orbitrap Orbitrap Orbitrap Orbitrap
MS instrument name Thermo Orbitrap ID-X Tribrid Thermo Orbitrap ID-X Tribrid Thermo Orbitrap ID-X Tribrid Thermo Orbitrap ID-X Tribrid
Ion Mode POSITIVE NEGATIVE POSITIVE NEGATIVE
Units m/z m/z m/z m/z
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